Irfan Khan may refer to:
- Irrfan Khan (1967–2020), Indian actor
- Irfan Khan (Indian cricketer) (born 1988), Indian cricketer
- Irfan Khan (Pakistani cricketer) (born 2002), Pakistani cricketer
- Irfan Khan (singer) (born 1982), Pakistani Pushto singer
- Irfan Khan (footballer)
- Irfan Khan Pathan (born 1984), Indian former cricketer
- Irfan Khan, a suspect in the 2005 Ram Janmabhoomi attack
- Irfan Saadat Khan (born 1963), Pakistani jurist
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