John Case may refer to:
- John Case (Aristotelian writer) (died 1600), English Aristotelian writer
- John Case (astrologer) (1660–1700), English astrologer and quack doctor
- John Case (athlete) (1889–1975), American track and field athlete
- John Case (novelist), pseudonym for Jim Hougan (born 1942) and Carolyn Hougan (1943–2007)
- John Higley Case (1832–1890), American politician
- John S. Case (1823–1902), Republican politician from Maine
- John Carol Case (1923–2012), English baritone
See also
- John Case Schaeffer II (born 1946), American musician
- John Casey (disambiguation)
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