Joseph Murphy may refer to:

Politicians

• Joseph Murphy (Irish politician), Irish independent politician who represented Dublin County, 1927–32
• Joseph Richard Murphy (1880–1944), Canadian politician
• Joseph Warner Murphy (1892–1977), Canadian Member of Parliament
• Joseph P. Murphy (1899–?), American politician, Wisconsin State Assemblyman
• Joseph L. Murphy (1907–1973), American politician in Massachusetts
• Joseph C. Murphy (1907–1987), American politician, Michigan State Representative

Sportsmen

• Joe Murphy (baseball) (1866–1951), pitcher in Major League Baseball
• Joe Murphy (footballer, born 1873) (1873–?), English football player for Hibernian, Stoke City, Arsenal and Raith Rovers
• Joe Murphy (American football) (1897–1940), Texas A&M University–Commerce head football coach
• Joe Murphy (Australian footballer) (1931–1985), Australian rules footballer
• Joe Murphy (hurler) (1947–2009), Irish hurler
• Joe Murphy (ice hockey) (born 1967), Canadian ice hockey player
• Joseph Murphy (equestrian) (born 1976), Irish equestrian
• Joe Murphy (footballer, born 1981), Irish football player for Tranmere Rovers, Scunthorpe United and Coventry City

Others

• Joseph Murphy (author) (1898–1981), author and lecturer on the subconscious
• Joseph Anthony Murphy (1857–1939), Roman Catholic bishop in Belize
• Joseph F. Murphy Jr. (1944-2022), American lawyer and jurist from Maryland
• Joe Murphy (actor) (1877–1961), American actor "The Gumps" etc
• Joseph S. Murphy (1933–1998), American President of Queens College, President of Bennington College, and Chancellor of the City University of New York
• Joseph T. Murphy (1910–1992), American lawyer and judge from Philadelphia
• Joe Murphy (Irish republican) (1895–1920), hunger striker
• Joey Murphy, American screenwriter and producer
• Joseph Murphy (priest) (born 1968), Head of Protocol at the Holy See's Secretariat of State
• Joe Murphy (contractor) (1917-2000), Irish civil engineering contractor