Katherine or Catherine Hughes may refer to:
- Katherine Hughes (activist) (1876–1925), Canadian writer, archivist and political activist
- Catherine Hughes (diplomat) (1933–2014), British diplomat and principal of Somerville College, Oxford
- Cathy Hughes (born 1947), American TV personality
- Kathryn Hughes (born 1959), British historian, journalist and biographer
- Catherine Andrea Hughes, Guyanese politician
- Katherine Hughes (actress) (born 1995), American actress
- Kate Hughes, fictional character on Emmerdale
- Catherine Hughes Building, a building of Somerville College, Oxford
See also
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