Li3 or LI3 may refer to:
- Li3 (software), a full-stack web framework for producing web applications
- Lithium (3Li), an isotope of oxygen, a chemical element with symbol Li and atomic number 3
- Lithium-3 (Li-3 or 3Li), a hypothetical isotope of lithium with no neutrons
- "Trilithium", a fictional chemical compound in Star Trek
- "Less interesting three" (LI3), nickname for Aerosmith members Tom Hamilton, Joey Kramer, and Brad Whitford (those not in the "Toxic Twins")
See also
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