Louis Jacobs may refer to:
- Louis Jacobs (1920–2006), a Masorti rabbi in the United Kingdom
- Louis L. Jacobs, American vertebrate paleontologist
- Louis Jacobs (businessman). American businessman and sports team owner
- Lou Jacobs (footballer) (1884–1936), Australian rules footballer
See also
- Lewis Jacobs (1904–1997), American author, director and publisher
- Lou Jacobs (1903–1992), an auguste clown
- Louis Jacob (disambiguation)
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