Luis Hurtado de Mendoza y Pacheco, 2nd Marquess of Mondéjar (born 1489 in Mondejar, Guadalajara, Spain; died 19 December 1566) was a Spanish nobleman.

He was the son of Íñigo López de Mendoza y Quiñones, second Count of Tendilla (born Guadalajara 1440; died Granada, Spain, 15 July 1515).
He was the first member of the House of Mendoza that supported Charles of Habsburg during the Revolt of the Comuneros, despite the fact that his own sister María Pacheco and her husband Juan López de Padilla were amongst the leaders of the revolt.

In 1525, he led a failed attempt to reconquer Peñón de Vélez de la Gomera. He remained loyal to King Charles for his entire life and received many important titles and functions.
He became the third Count of Tendilla; Viceroy of Navarre in 1543–1546; President of the Council of Indies in 1546–1559; and President of the Council of Castile in 1561–1563.

He married with Catalina Mendoza y Zúñiga and had

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