Luke McDonald or MacDonald may refer to:
People
- Luke McDonald, musician, lead guitar player in Sunk Loto
- Luke McDonald (footballer) (born 1995), drafted to North Melbourne in 2013
Fictional characters
- Luke McDonald (True Blood)
- Luke MacDonald, fictional character in El Dorado (1966 film)
- Luke MacDonald (fictional character), see List of Parker Lewis Can't Lose episodes
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