MSFS may refer to:
- Master of Science in Financial Services, a graduate degree for the financial services industry offered by some institutions. One such degree is awarded since 1927 by the American College of Financial Services in Bryn Mawr, PA.
- Master of Science in Foreign Service, a graduate degree in international affairs awarded since 1922 by the Edmund A. Walsh School of Foreign Service at Georgetown University, Washington, D.C.
- Master of Science in Forensic Science, a graduate degree in criminology awarded by a number of universities. One such degree is awarded by the John Jay College of Criminal Justice at City University of New York (CUNY).
- Master of Science in Financial Management and Information Systems, an executive graduate degree preparing mid-career professionals for the role of CIO/CFO. One such degree is awarded by the University of Maryland University College (UMUC).
- Microsoft Flight Simulator, a series of flight simulator video games.
- Microsoft Flight Simulator, the 2020 edition of the series.
- Missionaries of St. Francis de Sales, a Catholic religious group founded in response to the desire of St. Francis de Sales to found a society of missionary priests.
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