Margaret Shelton may refer to:
- Margaret (Madge) Shelton, possible mistress of Henry VIII of England
- Margaret Shelton (artist) (1915–1983), Canadian artist
- Meg Shelton (died 1705), alleged witch
- Margaret Sheldon, one of two known as "Doughnut Girls" (or "Doughnut Dollies"); see National Doughnut Day
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