Medelsheim is a surname. Notable people with the surname include:
- Herz Cerfbeer of Medelsheim (1730–1793), French Jewish philanthropist
- Maximilien Charles Alphonse Cerfberr of Medelsheim (1817—1883), French journalist, writer, and governmental official
- Samson Cerfberr of Medelsheim (1780–1826), French soldier and author
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