Mesa is the surname of:

• Antonio Mesa (fl. 1902–1905), Cuban baseball player, member of the Cuban Baseball Hall of Fame
• Arnaldo Mesa (1967–2012), Cuban boxer
• Carlos Mesa (born 1953), Bolivian historian and former politician
• Cristóbal de Mesa (1559–1633), Spanish Mannerist poet and writer
• Eddie Mesa (born 1940), Filipino actor and singer
• José Mesa (born 1966), American baseball pitcher
• Juan de Mesa (1583–1627), Spanish Baroque sculptor
• Juan Carlos Mesa (1930–2016), Argentine humorist, screenwriter and director
• Liana Mesa (born 1977), Cuban volleyball player
• Maikel Mesa (born 1991), Spanish footballer
• Manuel Mesa (born 1952), Spanish retired footballer
• Melky Mesa (born 1987), Dominican professional baseball outfielder
• Milena Mesa (born 1993), Cuban team handball player
• Raúl Mesa (born 1982), Spanish beach volleyball player
• Roque Mesa (born 1989), Spanish footballer
• Ubaldo Mesa (1973–2005), Colombian cyclist
• Uberlino Mesa (born 1971), Colombian cyclist
• Víctor Mesa (born 1960), Cuban baseball player
• Vilma Mesa (born 1963), Colombian-American mathematics educator
• Yosniel Mesa (born 1980), Cuban football forward
• Nano Mesa (born 1995), Spanish footballer