Mesirow is a surname of Slavic origin, meaning "dweller on a row between ditches". Notable people with the surname include:
- Cameron Mesirow (born 1983), better known as Glasser, American singer, songwriter, and record producer
- Milton Mesirow (1899-1972), American jazz clarinetist and saxophonist
See also
- Mesirow Financial, a financial services company based in Chicago, Illinois
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