Naked cuticle 2 (NKD2) is a human gene that encodes the protein Nkd2, one of the Naked cuticle (Nkd) family of proteins that regulate the Wnt signaling pathway.[1][2] Both Nkd1 and Nkd2 proteins can bind to Dishevelled proteins (DVL1, DVL2, DVL3), but only Nkd2 can bind to the EGF-ligand family member TGF alpha and regulate its polarized secretion in cultured epithelial cells.[3]

Sources

  1. ↑ Wharton, KA Jr; Zimmermann, G; Rousset, R; Scott, MP (Jun 2001). "Vertebrate proteins related to Drosophila Naked Cuticle bind Dishevelled and antagonize Wnt signaling". Dev. Biol. 234 (1): 93–106. doi:10.1006/dbio.2001.0238. PMID 11356022. S2CID 18903944.
  2. ↑ Katoh, M (Nov 2001). "Molecular cloning, gene structure, and expression analyses of NKD1 and NKD2". Int J Oncol. 19 (5): 963–9. doi:10.3892/ijo.19.5.963. PMID 11604995.
  3. ↑ Li, C; Franklin, JL; Graves-Deal, R; Jerome, WG; Cao, Z; Coffey, RJ (Apr 2004). "Myristoylated Naked2 escorts transforming growth factor alpha to the basolateral plasma membrane of polarized epithelial cells". Proc Natl Acad Sci U S A. 101 (15): 5571–6. Bibcode:2004PNAS..101.5571L. doi:10.1073/pnas.0401294101. PMC 397424. PMID 15064403.
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