NUCB2
Identifiers
AliasesNUCB2, HEL-S-109, NEFA, nucleobindin 2
External IDsOMIM: 608020 MGI: 1858179 HomoloGene: 3676 GeneCards: NUCB2
Orthologs
SpeciesHumanMouse
Entrez

4925

53322

Ensembl

ENSG00000070081

ENSMUSG00000030659

UniProt

P80303

P81117

RefSeq (mRNA)

NM_001130479
NM_016773
NM_001360375

RefSeq (protein)

NP_001123951
NP_001347304

Location (UCSC)Chr 11: 17.21 – 17.35 MbChr 7: 116.1 – 116.14 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nucleobindin-2 is a protein that when found in humans is encoded by the NUCB2 gene.[5][6]

Nucleobindin-2 is a calcium-binding EF-hand protein.[supplied by OMIM][6]

NUCB2 is protein precursor of nesfatin-1

In the study of the evolution of nervous systems, NUCB2 together with SMIM20 have been found to have deep homology across all lineages that preceded creatures with central nervous systems, bilaterians, cnidarians, ctenophores, and sponges as well as in choanoflagellates.[7][8]

Interactions

NUCB2 has been shown to interact with NDN.[9]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000070081 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030659 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Barnikol-Watanabe S, Gross NA, Götz H, Henkel T, Karabinos A, Kratzin H, et al. (August 1994). "Human protein NEFA, a novel DNA binding/EF-hand/leucine zipper protein. Molecular cloning and sequence analysis of the cDNA, isolation and characterization of the protein". Biological Chemistry Hoppe-Seyler. 375 (8): 497–512. doi:10.1515/bchm3.1994.375.8.497. PMID 7811391.
  6. 1 2 "Entrez Gene: NUCB2 nucleobindin 2".
  7. Yañez-Guerra LA, Thiel D, Jékely G (April 2022). O'Connell M (ed.). "Premetazoan Origin of Neuropeptide Signaling". Molecular Biology and Evolution. 39 (4): msac051. doi:10.1093/molbev/msac051. PMC 9004410. PMID 35277960.
  8. Callier V (2022-06-03). "Brain-Signal Proteins Evolved Before Animals Did". Quanta Magazine. Retrieved 2022-06-03.
  9. Taniguchi N, Taniura H, Niinobe M, Takayama C, Tominaga-Yoshino K, Ogura A, Yoshikawa K (October 2000). "The postmitotic growth suppressor necdin interacts with a calcium-binding protein (NEFA) in neuronal cytoplasm". The Journal of Biological Chemistry. 275 (41): 31674–31681. doi:10.1074/jbc.M005103200. PMID 10915798.

Further reading

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