Otto Franke is the name of:
- Otto Franke (sinologist) (1863–1946), German historian of China
- Otto Franke (politician) (1877–1953), German Communist politician and labor activist
See also
- Otto Frank (1889–1980), German businessman
- Otto Frank (physiologist) (1865–1944), German physiologist
- Otto Frankel (1900–1998), Austrian-born Australian geneticist
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