P2RX6
Identifiers
AliasesP2RX6, P2RXL1, P2X6, P2XM, purinergic receptor P2X 6
External IDsOMIM: 608077 MGI: 1337113 HomoloGene: 3975 GeneCards: P2RX6
Orthologs
SpeciesHumanMouse
Entrez

9127

18440

Ensembl

ENSG00000099957

ENSMUSG00000022758

UniProt

O15547

O54803

RefSeq (mRNA)

NM_001159561
NM_011028

RefSeq (protein)

NP_001153026
NP_005437
NP_001336803
NP_001336804
NP_001336805

NP_001153033
NP_035158

Location (UCSC)Chr 22: 21.01 – 21.03 MbChr 16: 17.38 – 17.4 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

P2X purinoceptor 6 is a protein that in humans is encoded by the P2RX6 gene.[5][6][7][8]

The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells.[8]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000099957 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022758 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Urano T, Nishimori H, Han H, Furuhata T, Kimura Y, Nakamura Y, Tokino T (Sep 1997). "Cloning of P2XM, a novel human P2X receptor gene regulated by p53". Cancer Res. 57 (15): 3281–7. PMID 9242461.
  6. Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
  7. Collo G, North RA, Kawashima E, Merlo-Pich E, Neidhart S, Surprenant A, Buell G (Sep 1996). "Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels". J Neurosci. 16 (8): 2495–507. doi:10.1523/JNEUROSCI.16-08-02495.1996. PMC 6578782. PMID 8786426.
  8. 1 2 "Entrez Gene: P2RXL1 purinergic receptor P2X-like 1, orphan receptor".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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