PRL may refer to:
Places
- Polish People's Republic (Polska Rzeczpospolita Ludowa), 1952–1989
- Punggol Regional Library, an upcoming regional library in Punggol, Singapore
Business and enterprises
- Penn Eastern Rail Lines, reporting mark
Computing and technology
- Preferred Roaming List, in CDMA phones
- Proportional reduction in loss, a measure of reliability
- Protocol-relative link, URLs which do not specify a protocol
Political parties
- Liberal Reformist Party (Dominican Republic)
- Parti Réformateur Libéral, a former political party in Belgium
- Party of the Radical Left (Partija radikalne levice), a political party in Serbia
- Republican Party of Liberty, a conservative political party in France, 1945–1951
Other organisations
- Premiership Rugby Limited, the organising body of Premiership Rugby
Science and healthcare
- Physical Research Laboratory, India
- Physical Review Letters, a scientific journal
- PRL-8-53, Nootropic research chemical
- Prolactin, a hormone
Other
- Parramatta Rail Link, a formerly proposed railway project in Sydney, Australia
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