Patrick or Paddy Agnew may refer to:
- Sir Patrick Agnew, 1st Baronet (c. 1578–1661), Member of Parliament for Wigtownshire, 1628–1633 and 1643–1647
- Paddy Agnew (Stormont MP) (1878–fl. 1958), Northern Ireland Labour Party MP for South Armagh 1938–1945
- Paddy Agnew (Irish republican) (born 1955), former IRA volunteer elected to Dáil Éireann during the 1981 Irish Hunger Strike
- Patrick Alexander Agnew (1765–1813), governor of British Ceylon, 1795–1796
- Patrick Alexander Vans Agnew (1822–1848), British civil servant of the East India Company
- Paddy Agnew (rugby union), Irish rugby union player
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