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Palfrey is an occupational surname, denoting a person responsible for the maintenance and provision of saddle horses. Notable people with the surname include:

• Daf Palfrey (born 1973), Welsh television, film and video director, producer and writer
• Deborah Jeane Palfrey (1956–2008), operated an escort agency in Washington, D.C., convicted in 2008 of racketeering, money laundering, etc.
• Francis Winthrop Palfrey (1831–1889), American historian, born in Boston, Massachusetts son of J. G. Palfrey
• John G. Palfrey (1796–1881), American clergyman and historian who served as a U.S. Representative from Massachusetts
• John Palfrey (born 1972), faculty co-director of the Berkman Center for Internet & Society at Harvard Law School
• Judith Palfrey (born 1943), the T. Berry Brazelton Professor of Pediatrics at Harvard Medical School
• Lisa Palfrey, Welsh television actress best known for playing the character of Rhiannedd Frost in the Welsh soap Pobol y Cwm
• Sarah Palfrey Cooke (1912–1996), female tennis player from the United States
• Sean Palfrey (born 1968), Welsh professional darts player who currently plays in the Professional Darts Corporation
• Simon Palfrey, English Scholar at Oxford University and a Fellow in English at Brasenose College, Oxford University
• Stephen Palfrey Webb (1804–1879), 3rd & 12th Mayor of Salem, Massachusetts (1842–1845, 1860–1862) and 6th Mayor of San Francisco (1854–1855)
• Thomas Palfrey (born 1953), currently (as of 2007) the Flintridge Professor of Economics and Political Science at the California Institute of Technology
• William Palfrey (1741–1780), American Patriot born in Boston, Massachusetts
• Yolande Palfrey (1957–2011), British actress

See also

• Mr. Palfrey of Westminster, British television drama which ran in 1984–85
• Mrs. Palfrey at the Claremont, 2005 comedy-drama film made by Claremont Films