Panagopoulos (Greek: Παναγόπουλος) is a Greek surname. Notable people with the surname include:

• Andreas Panagopoulos (1883–1952), Greek politician
• Costas Panagopoulos, American political scientist
• Leonidas Panagopoulos (born 1987), Greek footballer
• Nicolas Panagopoulos (born 1954), Greek composer
• Panayotis Panagopoulos (1916–unknown), Greek chess player
• Pericles Panagopoulos (1935–2019), Greek shipping magnate