Pánfilo de Narváez (1478–1528) was a Spanish conquistador and soldier.

The name Panfilo is the Italian and Spanish form of the Latin name Pamphilus. Other notable people named Panfilo include:

• Pamphilus of Sulmona (7th century – 8th century), an Italian bishop and saint
• Panfilo Castaldi (c. 1398 – c. 1490), an Italian physician and printer
• Panfilo Gentile (1889–1971), an Italian journalist, writer and politician
• Panfilo Nuvolone (1581–1651), an Italian painter
• Pánfilo Natera García, a Mexican general and politician who served as Governor of Zacatecas
• Panfilo Lacson (born 1948), a Filipino police officer and politician
• Pánfilo Escobar (born 1974), a Paraguayan footballer