Pedro Manuel Colón de Portugal y de la Cueva, 7th Duke of Veragua, (25 December 1651 – 9 September 1710) was a Spanish noble.

He was a Knight of the Order of the Golden Fleece since 1675, Viceroy of Valencia, 1679–1680, Viceroy of Sicily, 1696–1701, and Viceroy of Sardinia, 1706–1708.

He was born in Madrid, the eldest son of Pedro Nuño Colón de Portugal, 6th Duke of Veragua and 5th Duke of la Vega, a descendant of the House of Braganza, and his first wife, Isabel Fernández de la Cueva y Enríquez de Cabrera, daughter of Francisco Fernández de la Cueva, 7th Duke of Alburquerque.

Pedro Manuel married Teresa Marina de Ayala, 4th Marchioness de la Mota, in Madrid on 30 August 1674.

Their eldest son was Pedro Manuel Nuño Colón de Portugal y Ayala. After his death in 1733, his sister Catalina Ventura, deceased 1739, became 9th Duchess of Veragua; but because she had married on 31 December 1716 Madrid James Francis FitzJames Stuart y Burgh, their children inherited Spanish and a few British titles.

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