Pleurotoma may refer to:
- Pleurotoma Lamarck, 1799 , a genus of gastropods in the family Turridae, synonym of Turris
- Pleurotoma Mörch, 1869, a genus of gastropods in the family Mangeliidae, synonym of Oenopota
- Pleurotoma, a fossil genus of sponges in the order Lychniscosida, family unknown, synonym of Jima
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