RPL31
Identifiers
AliasesRPL31, L31, ribosomal protein L31
External IDsOMIM: 617415 MGI: 2149632 HomoloGene: 133014 GeneCards: RPL31
Orthologs
SpeciesHumanMouse
Entrez

6160

114641

Ensembl

ENSG00000071082

ENSMUSG00000073702

UniProt

H7C2W9

P62900

RefSeq (mRNA)

NM_001099693
NM_000993
NM_001098577

NM_001252218
NM_001252219
NM_053257

RefSeq (protein)

n/a

NP_001239147
NP_001239148
NP_444487

Location (UCSC)Chr 2: 101 – 101.02 MbChr 1: 39.41 – 39.41 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

60S ribosomal protein L31 is a protein that in humans is encoded by the RPL31 gene.[5][6][7]

Function

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L31E family of ribosomal proteins. It is located in the cytoplasm. Higher levels of expression of this gene in familial adenomatous polyps compared to matched normal tissues have been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[7]

Interactions

RPL31 has been shown to interact with BRCA1.[8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000071082 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000073702 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Nobori T, Hexdall LE, Carson DA (September 1989). "cDNA sequence of human ribosomal protein L31". Nucleic Acids Research. 17 (17): 7105. doi:10.1093/nar/17.17.7105. PMC 318439. PMID 2780320.
  6. Yoshihama M, Uechi T, Asakawa S, Kawasaki K, Kato S, Higa S, Maeda N, Minoshima S, Tanaka T, Shimizu N, Kenmochi N (March 2002). "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes". Genome Research. 12 (3): 379–90. doi:10.1101/gr.214202. PMC 155282. PMID 11875025.
  7. 1 2 "Entrez Gene: RPL31 ribosomal protein L31".
  8. Yarden RI, Brody LC (2001). "Identification of proteins that interact with BRCA1 by Far-Western library screening". Journal of Cellular Biochemistry. 83 (4): 521–31. doi:10.1002/jcb.1257. PMID 11746496. S2CID 29703139.

Further reading


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