RSU1
Identifiers
AliasesRSU1, RSP-1, Ras suppressor protein 1
External IDsOMIM: 179555 MGI: 103040 HomoloGene: 7521 GeneCards: RSU1
Orthologs
SpeciesHumanMouse
Entrez

6251

20163

Ensembl

ENSG00000148484

ENSMUSG00000026727

UniProt

Q15404

Q01730

RefSeq (mRNA)

NM_012425
NM_152724

NM_009105

RefSeq (protein)

NP_036557
NP_689937

n/a

Location (UCSC)Chr 10: 16.59 – 16.82 MbChr 2: 13.08 – 13.28 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ras suppressor protein 1 is a protein that in humans is encoded by the RSU1 gene.[5][6]

This gene encodes a protein that is involved in the Ras signal transduction pathway, growth inhibition, and nerve-growth factor induced differentiation processes, as determined in mouse and human cell line studies. In mouse, the encoded protein was initially isolated based on its ability to inhibit v-Ras transformation. Multiple alternatively spliced transcript variants for this gene have been reported; one of these variants was found only in glioma tumors.[6] RSU-1 has also been seen to act as a structural protein in integrin-mediated focal-adhesion complexes. It bind strongly to the protein PINCH.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000148484 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026727 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Tsuda T, Cutler ML (Feb 1994). "Human RSU1 is highly homologous to mouse Rsu-1 and localizes to human chromosome 10". Genomics. 18 (2): 461–2. doi:10.1006/geno.1993.1503. PMID 8288261.
  6. 1 2 "Entrez Gene: RSU1 Ras suppressor protein 1".

Further reading


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