RUVBL1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRUVBL1, ECP54, INO80H, NMP238, PONTIN, Pontin52, RVB1, TIH1, TIP49, TIP49A, ECP-54, NMP 238, RuvB like AAA ATPase 1
External IDsOMIM: 603449 MGI: 1928760 HomoloGene: 37839 GeneCards: RUVBL1
Orthologs
SpeciesHumanMouse
Entrez

8607

56505

Ensembl

ENSG00000175792
ENSG00000284901

ENSMUSG00000030079

UniProt

Q9Y265

P60122

RefSeq (mRNA)

NM_003707
NM_001319084
NM_001319086

NM_019685

RefSeq (protein)

NP_001306013
NP_001306015
NP_003698

NP_062659

Location (UCSC)Chr 3: 128.06 – 128.15 MbChr 6: 88.44 – 88.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

RuvB-like 1 (E. coli), also known as RUVBL1 and TIP49, is a human gene.[5] RUVBL1 can form a hexamer. The hexamer can form a dodecamer with RUVBL2 protein.[6] Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity.

Interactions

RuvB-like 1 has been shown to interact with:

References

  1. 1 2 3 ENSG00000284901 GRCh38: Ensembl release 89: ENSG00000175792, ENSG00000284901 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030079 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: RUVBL1 RuvB-like 1 (E. coli)".
  6. Puri T, Wendler P, Sigala B, Saibil H, Tsaneva IR (February 2007). "Dodecameric structure and ATPase activity of the human TIP48/TIP49 complex". J. Mol. Biol. 366 (1): 179–92. doi:10.1016/j.jmb.2006.11.030. PMID 17157868.
  7. 1 2 Park J, Wood MA, Cole MD (March 2002). "BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation". Mol. Cell. Biol. 22 (5): 1307–16. doi:10.1128/mcb.22.5.1307-1316.2002. PMC 134713. PMID 11839798.
  8. Bauer A, Huber O, Kemler R (Dec 1998). "Pontin52, an interaction partner of beta-catenin, binds to the TATA box binding protein". Proc. Natl. Acad. Sci. U.S.A. 95 (25): 14787–92. Bibcode:1998PNAS...9514787B. doi:10.1073/pnas.95.25.14787. PMC 24527. PMID 9843967.
  9. 1 2 Fuchs M, Gerber J, Drapkin R, Sif S, Ikura T, Ogryzko V, Lane WS, Nakatani Y, Livingston DM (August 2001). "The p400 complex is an essential E1A transformation target". Cell. 106 (3): 297–307. doi:10.1016/s0092-8674(01)00450-0. PMID 11509179. S2CID 15634637.
  10. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

Further reading


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