Robert Clayton may refer to:
- Robert Clayton (bishop) (1695–1758), Irish Protestant bishop
- Robert Clayton (City of London MP) (1629–1707), Lord Mayor of London, MP for the City of London and for Bletchingley
- Robert Clayton (cricketer) (1844–1901), Welsh cricketer
- Sir Robert James Clayton (1915–1998), British electronics engineer and executive
- Robert N. Clayton (1930–2017), Canadian-American National Medal of Science laureate
- Rob Clayton, American painter, one of the Clayton Brothers
- Bob Clayton (1922–1979), American game show host
- Bob Clayton (footballer), Australian rules footballer
- Clayton baronets:
- Sir Robert Clayton, 2nd Baronet, of Adlington (1746–1839)
- Sir Robert Clayton, 3rd Baronet, of Marden (c. 1740–1799), MP for several seats
- Sir Robert Alan Clayton-East-Clayton, 9th Baronet Clayton, of Marden (1908–1932)
- Sir Robert Alan Clayton East-Clayton, 5th Baronet of Hall Place, Maidenhead (1908–1932)
- Sir Robert Clayton, 13th Baronet of Marden (1975-)
See also
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