Rue or Rué is the surname of:

• Danica Rue (born 1982), American weightlifter
• Gérard Rué (born 1965), French former cyclist
• Jean-Baptiste Rué (born 1974), French former rugby union player
• Joe Rue (1898-1984), American Major League Baseball umpire
• Joseph Rue, French World War II vice-admiral
• Lea Rue, stage name of Belgian singer-songwriter Emma Lauwers (born 1993)
• Loyal Rue (born 1944), American philosopher and writer
• Marcel Rué (born 1926), Monegasque sports shooter
• Nancy Rue, American Christian novelist
• Rosemary Rue (1928-2004), British physician and civil servant
• Sander Rue (born 1954), American politician
• Sara Rue, American television actress born Sara Schlackman in 1979