| SGO1 | |||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||
| Aliases | SGO1, NY-BR-85, SGO, Sgo1, CAID, SGOL1, shugoshin 1 | ||||||||||||||||||||||||||||||
| External IDs | OMIM: 609168 MGI: 1919665 HomoloGene: 23642 GeneCards: SGO1 | ||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||
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Shugoshin 1 or Shugoshin-like 1, is a protein that in humans is encoded by the SGO1 gene.[5][6][7]
Mechanisms
A physical mechanism that guarantees the accurate segregation of sister chromatids during mitosis arises from the ring shaped cohesin complex consisting of 4 subunits (SMC1A/B, SMC3, SCC1, and SA1/2 in humans). This complex encircles the two sister chromatids and resists the pulling force of microtubules.[8] The characteristic X-shape chromosomes are formed due to the centromeric cohesin protected by Shugoshin-PP2A complex.[9]
Kinetochore localization of Sgo1-PP2A is dependent upon phosphorylation on histone H2A of nucleosome, which is the important substrate of spindle checkpoint kinase BUB1.[10] Centromeric cohesin and H2A-pT120 specify two distinct pools of Sgo1-PP2A at inner centromeres and kinetochores respectively,[11] while the CDK1/cyclin B phosphorylation on Sgo1 is essential for Sgo1-PP2A to protect centromeric cohesin, not only for bringing PP2A to cohesin,[12] but also physically shield out the negative regulator WAPAL from cohesin.[13]
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000129810 - Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023940 - Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "UniProt". www.uniprot.org. Retrieved 6 November 2022.
- ↑ Scanlan MJ, Gout I, Gordon CM, Williamson B, Stockert E, Gure AO, Jäger D, Chen YT, Mackay A, O'Hare MJ, Old LJ (Mar 2001). "Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression". Cancer Immunity. 1: 4. PMID 12747765.
- ↑ "Entrez Gene: SGOL1 shugoshin-like 1 (S. pombe)".
- ↑ Nasmyth K, Haering CH (2009). "Cohesin: its roles and mechanisms". Annual Review of Genetics. 43: 525–58. doi:10.1146/annurev-genet-102108-134233. PMID 19886810.
- ↑ Kitajima TS, Sakuno T, Ishiguro K, Iemura S, Natsume T, Kawashima SA, Watanabe Y (May 2006). "Shugoshin collaborates with protein phosphatase 2A to protect cohesin". Nature. 441 (7089): 46–52. Bibcode:2006Natur.441...46K. doi:10.1038/nature04663. PMID 16541025. S2CID 4425074.
- ↑ Kawashima SA, Yamagishi Y, Honda T, Ishiguro K, Watanabe Y (Jan 2010). "Phosphorylation of H2A by Bub1 prevents chromosomal instability through localizing shugoshin". Science. 327 (5962): 172–7. Bibcode:2010Sci...327..172K. doi:10.1126/science.1180189. PMID 19965387. S2CID 41673818.
- ↑ Liu H, Jia L, Yu H (Oct 2013). "Phospho-H2A and cohesin specify distinct tension-regulated Sgo1 pools at kinetochores and inner centromeres". Current Biology. 23 (19): 1927–33. doi:10.1016/j.cub.2013.07.078. PMID 24055156.
- ↑ Liu H, Rankin S, Yu H (Jan 2013). "Phosphorylation-enabled binding of SGO1-PP2A to cohesin protects sororin and centromeric cohesion during mitosis". Nature Cell Biology. 15 (1): 40–9. doi:10.1038/ncb2637. PMC 3531828. PMID 23242214.
- ↑ Hara K, Zheng G, Qu Q, Liu H, Ouyang Z, Chen Z, Tomchick DR, Yu H (Oct 2014). "Structure of cohesin subcomplex pinpoints direct shugoshin-Wapl antagonism in centromeric cohesion". Nature Structural & Molecular Biology. 21 (10): 864–70. doi:10.1038/nsmb.2880. PMC 4190070. PMID 25173175.
Further reading
- Wang X, Dai W (Oct 2005). "Shugoshin, a guardian for sister chromatid segregation". Experimental Cell Research. 310 (1): 1–9. doi:10.1016/j.yexcr.2005.07.018. PMID 16112668.
- Fu G, Ding X, Yuan K, Aikhionbare F, Yao J, Cai X, Jiang K, Yao X (Jul 2007). "Phosphorylation of human Sgo1 by NEK2A is essential for chromosome congression in mitosis". Cell Research. 17 (7): 608–18. doi:10.1038/cr.2007.55. PMID 17621308.
- Pouwels J, Kukkonen AM, Lan W, Daum JR, Gorbsky GJ, Stukenberg T, Kallio MJ (Jul 2007). "Shugoshin 1 plays a central role in kinetochore assembly and is required for kinetochore targeting of Plk1". Cell Cycle. 6 (13): 1579–85. doi:10.4161/cc.6.13.4442. PMID 17617734.
- Fu G, Hua S, Ward T, Ding X, Yang Y, Guo Z, Yao X (Jun 2007). "D-box is required for the degradation of human Shugoshin and chromosome alignment". Biochemical and Biophysical Research Communications. 357 (3): 672–8. doi:10.1016/j.bbrc.2007.03.204. PMID 17448445.
- Yang Y, Wang X, Dai W (Apr 2006). "Human Sgo1 is an excellent target for induction of apoptosis of transformed cells". Cell Cycle. 5 (8): 896–901. doi:10.4161/cc.5.8.2691. PMID 16628005.
- Tang Z, Shu H, Qi W, Mahmood NA, Mumby MC, Yu H (May 2006). "PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation". Developmental Cell. 10 (5): 575–85. doi:10.1016/j.devcel.2006.03.010. PMID 16580887.
- Kitajima TS, Sakuno T, Ishiguro K, Iemura S, Natsume T, Kawashima SA, Watanabe Y (May 2006). "Shugoshin collaborates with protein phosphatase 2A to protect cohesin". Nature. 441 (7089): 46–52. Bibcode:2006Natur.441...46K. doi:10.1038/nature04663. PMID 16541025. S2CID 4425074.
- McGuinness BE, Hirota T, Kudo NR, Peters JM, Nasmyth K (Mar 2005). "Shugoshin prevents dissociation of cohesin from centromeres during mitosis in vertebrate cells". PLOS Biology. 3 (3): e86. doi:10.1371/journal.pbio.0030086. PMC 1054882. PMID 15737064.
- Kitajima TS, Hauf S, Ohsugi M, Yamamoto T, Watanabe Y (Feb 2005). "Human Bub1 defines the persistent cohesion site along the mitotic chromosome by affecting Shugoshin localization". Current Biology. 15 (4): 353–9. doi:10.1016/j.cub.2004.12.044. PMID 15723797. S2CID 18249910.
- Tang Z, Sun Y, Harley SE, Zou H, Yu H (Dec 2004). "Human Bub1 protects centromeric sister-chromatid cohesion through Shugoshin during mitosis". Proceedings of the National Academy of Sciences of the United States of America. 101 (52): 18012–7. Bibcode:2004PNAS..10118012T. doi:10.1073/pnas.0408600102. PMC 539817. PMID 15604152.
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