Saint Francis High School may refer to:

• Saint Francis High School (Calgary), Alberta, Canada

United States (sorted by state):

• Saint Francis High School (La Cañada Flintridge, California)
• Saint Francis High School (Mountain View, California)
• St. Francis High School (Sacramento, California), an all-female college preparatory school
• Saint Francis Central Coast Catholic High School, Watsonville, California
• St. Francis High School (Gainesville, Florida), renamed St. Francis Catholic Academy in 2016
• St. Francis Schools (Atlanta area, Georgia), grades K-12 in Alpharetta, Georgia
• Saint Francis School (Hawaii), grades PK–12 in Honolulu, Hawaii
• St. Francis High School (Wheaton, Illinois)
• Saint Francis High School (Louisville), Kentucky
• St. Francis High School (Traverse City, Michigan)
• Saint Francis High School (Saint Francis, Minnesota)
• St. Francis High School (Humphrey, Nebraska)
• Saint Francis High School (Athol Springs), New York
• St. Francis Preparatory School, Queens, New York
• Saint Francis High School (St. Francis, Wisconsin)

See also

• List of schools named after Francis Xavier
• St. Francis Borgia Regional High School, Washington, Missouri
• St. Francis de Sales High School (disambiguation)