Samuel Burton may refer to:
- Samuel Burton (MP), 18th-century Irish MP
- Samuel S. Burton (1822–1892), American lawyer, judge, and banker in Wisconsin
- Samuel D. Burton (1887–1933) , American football and basketball coach
- Samuel Burton (priest), Anglican priest
- Sam Burton (1926–2020) was an English professional footballer
- Sammy Burton, American Negro league baseball player
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