Sante is both a masculine Italian given name and a surname. Notable people with the name include:

Given name:

• Sante Bentivoglio (1426–1462), Italian nobleman
• Sante Geronimo Caserio (1873–1894), Italian anarchist and assassin
• Sante Cattaneo (1739–1819), Italian Neoclassic painter
• Sante Ceccherini (1863–1932), Italian fencer
• Sante Gaiardoni (born 1939), Italian cyclist
• Sante Geminiani (1919–1951), Italian motorcycle racer
• Sante Graziani (1920–2005), American artist
• Sante Kimes (1934–2014), American murderer
• Sante Lombardo (1504–1560), Italian architect
• Sante Marsili (born 1950), Italian water polo player
• Sante Monachesi (born 1910), Italian painter
• Sante Poromaa (born 1958), Swedish Zen Buddhist priest
• Sante De Sanctis (1862–1935), Italian psychologist
• Sante Vandi (1653–1716), Italian Baroque painter

Surname:

• Lucy Sante (born 1954), Belgian-American writer and critic

See also

• "Santé" (song), a 2021 song by Belgian singer Stromae
• Sante River, river in Michigan, United States