Cochlear duct
Inner ear, with Cochlear Duct labeled near bottom.
Diagrammatic longitudinal section of the cochlea. (visible at far right under latin name ductus cochlearis)
Details
SystemEar
Identifiers
LatinDuctus Cochlearis
MeSHD003053
NeuroLex IDbirnlex_2562
TA98A15.3.03.093
A15.3.03.092
TA27022
FMA79789 61119, 79789
Anatomical terminology

The cochlear duct (a.k.a. the scala media) is an endolymph filled cavity inside the cochlea, located between the tympanic duct and the vestibular duct, separated by the basilar membrane and the vestibular membrane (Reissner's membrane) respectively. The cochlear duct houses the organ of Corti.[1]

Structure

The cochlear duct is part of the cochlea. It is separated from the tympanic duct (scala tympani) by the basilar membrane.[2] It is separated from the vestibular duct (scala vestibuli) by the vestibular membrane (Reissner's membrane).[2] The stria vascularis is located in the wall of the cochlear duct.[2]

Development

The cochlear duct develops from the ventral otic vesicle (otocyst).[3] It grows slightly flattened between the middle and outside of the body.[3] This development may be regulated by the genes EYA1, SIX1, GATA3, and TBX1.[3] The organ of Corti develops inside the cochlear duct.[4]

Function

The cochlear duct contains the organ of Corti.[2][5] This is attached to the basilar membrane.[5] It also contains endolymph, which contains high concentrations of K+ for the function of inner hair cells and outer hair cells in the organ of Corti.[2]

Clinical significance

Drugs delivered directly to the tympanic duct will spread to all of the cochlea except for the cochlear duct.[6] Rarely, the cochlear duct may develop to have the wrong shape.[3]

Additional images

References

  1. ↑ Hayes, Sarah H.; Ding, Dalian; Salvi, Richard J.; Allman, Brian L. (2013). "1 – Anatomy and physiology of the external, middle and inner ear". Handbook of Clinical Neurophysiology. Vol. 10. Elsevier. pp. 3–23. doi:10.1016/B978-0-7020-5310-8.00001-6. ISBN 978-0-7020-5310-8. ISSN 1567-4231.
  2. 1 2 3 4 5 Feher, Joseph (2012). "4.7 – Hearing". Quantitative Human Physiology – An Introduction (2nd ed.). Academic Press. pp. 440–455. doi:10.1016/B978-0-12-800883-6.00040-9. ISBN 978-0-12-800883-6.
  3. 1 2 3 4 Fekete, D. M. (2009). "Cochlear Development". Encyclopedia of Neuroscience. Academic Press. pp. 1031–1040. doi:10.1016/B978-008045046-9.00252-7. ISBN 978-0-08-045046-9.
  4. ↑ Goodyear, Richard J.; Richardson, Guy P. (2018). "6 – Structure, Function, and Development of the Tectorial Membrane: An Extracellular Matrix Essential for Hearing". Current Topics in Developmental Biology. Vol. 130. Elsevier. pp. 217–244. doi:10.1016/bs.ctdb.2018.02.006. ISBN 978-0-12-809802-8. ISSN 0070-2153. PMID 29853178.
  5. 1 2 Spelman, Francis A. (2013). "2.5.11 – Cochlear Prostheses". Biomaterials Science – An Introduction to Materials in Medicine (3rd ed.). Academic Press. pp. 967–980. doi:10.1016/B978-0-08-087780-8.00083-8. ISBN 978-0-12-374626-9.
  6. ↑ Shepherd, R. K.; Seligman, P. M.; Fallon, J. B. (2015). "5 – Neuroprostheses for restoring hearing loss". Implantable Neuroprostheses for Restoring Function. Woodhead Publishing. pp. 97–125. doi:10.1016/B978-1-78242-101-6.00005-7. ISBN 978-1-78242-101-6.
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