Sean Hughes may refer to:
- Sean Hughes (boxer) (born 1982), English boxer
- Sean Hughes (comedian) (1965–2017), English-born Irish stand-up comedian, writer and actor
- Sean Hughes (Irish republican), alleged IRA member
- Sean Hughes (politician) (1946–1990), British Labour Party Member of Parliament, 1983–1990
- Sean P. F. Hughes (born 1941), British emeritus professor of orthopaedic surgery
- Sean Hughes, bassist with Green Day
See also
- Shaun M. Hughes, Australian astronomer
- Hughes (surname)
- List of people named Sean
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