Shands may reference one of the following:
- William A. Shands, a Florida politician for whom the following are named:
- UF Health Shands Hospital, a medical center in Gainesville, Florida
- UF Health Jacksonville, a medical center in Jacksonville, Florida, formerly referred to as Shands Jacksonville
- Shands Bridge, which spans the St. Johns River south of Jacksonville, Florida
- Shands, California, a former settlement
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