The siege of Exeter may refer to:

• The Mercian Siege of Exeter (c. 630), also known as the Siege of Caer-Uisc. Almost certainly fictional.
• The Danish Siege of Exeter (893)
• The Siege of Exeter (1068), during the Norman Conquest of England
• The Siege of Exeter (1549) which took place during the Prayer Book Rebellion
• One of the sieges of Exeter that took place during the First English Civil War:
  • in 1643, by the Royalists
  • in 1645–6, by the Parliamentarians