Sikanni is a variant spelling of Sekani, the name of an Athapaskan people of northern British Columbia, Canada. It is found in various placenames and related uses:

• Sikanni Chief, British Columbia, an unincorporated settlement in British Columbia
• Sikanni Chief River, a tributary of the Fort Nelson River in British Columbia
• Sikanni Chief Lake, a lake near the headwaters of that river
• Sikanni Old Growth Provincial Park, a provincial park in British Columbia
• the Sikanni Range, a subrange of the Omineca Mountains of British Columbia
• CFAV Sikanni (YPT 611), a torpedo and sound ranging vessel of the Canadian Forces, named after the river