Sisco or Sisko may refer to:
- Sisco, Haute-Corse, a commune in Corsica, France
- Sisco (stream), a coastal stream in Corsica, France
- Sisco, Washington, a community in the United States
Persons with the surname
- Andrew Sisco (born 1983), American baseball pitcher
- Chance Sisco (born 1995), American baseball catcher
- Jack Sisco (1904–1983), American football player, coach, and official
- Kristina Sisco (born 1982), American actress
Fictional characters
- Karen Sisco, a United States Marshal created by novelist Elmore Leonard, also appearing in a television series and the film Out of Sight.
- From the television series, Star Trek: Deep Space Nine:
See also
- Sisqó (born 1978), American R&B singer, songwriter, record producer, dancer and actor
- Gene Siskel, American film critic and journalist
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