Tobacco smoking during pregnancy causes many detrimental effects on health and reproduction, in addition to the general health effects of tobacco. A number of studies have shown that tobacco use is a significant factor in miscarriages among pregnant smokers, and that it contributes to a number of other threats to the health of the foetus.[1][2][3]

Because of the associated risks, people are advised not to smoke before, during or after pregnancy. If this is not possible, however, reducing the daily number of cigarettes smoked can minimize the risks for both the mother and child. This is especially true for people in developing countries, where breastfeeding is essential for the child's overall nutritional status.[4]

Smoking before pregnancy

Women who are pregnant or planning to become pregnant are advised to stop smoking.[5][6] It is important to examine these effects because smoking before, during and after pregnancy is not an unusual behavior among the general population and can have detrimental health impacts, especially among both mother and child, as a result. In 2011, approximately 10% of pregnant women in data collected from 24 U.S. states reported smoking during the last three months of their pregnancy.[7]

According to a 1999 meta-analysis published in the American Journal of Preventive Medicine, smoking prior to pregnancy is strongly related to an increased risk of developing an ectopic pregnancy.[6]

Smoking during pregnancy

According to a study conducted in 2008 by the Pregnancy Risk Assessment Monitoring System (PRAMS) that interviewed people in 26 states in the United States, approximately 13% of women reported smoking during the last three months of pregnancy. Of women who smoked during the last three months of pregnancy, 52% reported smoking five or fewer cigarettes per day, 27% reported smoking six to 10 cigarettes per day, and 21% reported smoking 11 or more cigarettes per day.[8]

In the United States, women whose pregnancies were unintended are 30% more likely to smoke during pregnancy than those whose pregnancies were intended.[9]

Effects on ongoing pregnancy

Smoking during pregnancy can lead to a plethora of health risks and damage to both the mother and the fetus.

Women who smoke during pregnancy are about twice as likely to experience the following pregnancy complications:[10]

  • premature rupture of membranes, which means that the amniotic sac will rupture prematurely, and will induce labour before the baby is fully developed. Although this complication generally has a good prognosis (in Western countries), it causes stress as the premature child may have to stay in the hospital to gain health and strength to be able to sustain life on their own.
  • placental abruption, wherein there is premature separation of the placenta from the attachment site. The fetus can be put in distress, and can even die. The mother can lose blood and can have a haemorrhage; she may need a blood transfusion.
  • placenta previa, where in the placenta grows in the lowest part of the uterus and covers all or part of the opening to the cervix.[11] Having placenta previa is an economic stress as well because it requires having a caesarean section delivery, which require a longer recovery period in the hospital. There can also be complications, such as maternal hemorrhage.

According to a 1999 meta-analysis published in the American Journal of Preventive Medicine, smoking during pregnancy is related to a reduced risk of developing pre-eclampsia.[6]

Premature birth

Some studies show that the probability of premature birth is roughly 50% higher for women who smoke during pregnancy, going from around 8% to 11%.[12]

Implications for the umbilical cord

Smoking can also impair the general development of the placenta, which is problematic because it reduces blood flow to the fetus. When the placenta does not develop fully, the umbilical cord which transfers oxygen and nutrients from the mother's blood to the placenta, cannot transfer enough oxygen and nutrients to the fetus, which will not be able to fully grow and develop. These conditions can result in heavy bleeding during delivery that can endanger mother and baby, although cesarean delivery can prevent most deaths.[13]

Pregnancy-induced hypertension

There is limited evidence that smoking reduces the incidence of pregnancy-induced hypertension,[14] but not when the pregnancy is with multiple babies (i.e. it has no effect on twins, triplets, etc.).[15]

Tic disorders

Other effects of maternal smoking during pregnancy include an increased risk for Tourette syndrome and tic disorders. There is a link between chronic tic disorders, which include Tourette syndrome and other disorders like ADHD and OCD. According to a study published in 2016 in the Journal of the American Academy of Child and Adolescent Psychiatry, there is an especially high risk for children to be born with a chronic tic disorder if their mother is a heavy smoker. Heavy smoking can be defined as ten or more cigarettes each day. With this heavy smoking, researchers have found that there is an increase in risk as high as 66% for the child to have a chronic tic disorder. Maternal smoking during pregnancy is also associated with psychiatric disorders such as ADHD. Concerning the increase risk for Tourette syndrome, there is an increased risk when two or more psychiatric disorders are also existent as maternal smoking leads to a higher chance of having a psychiatric disorder.[16]

Cleft palate

Pregnant women who smoke may be at risk of having a child with cleft palate.[17]

Effects of smoking during pregnancy on the child after birth

Low birth weight

Smoking during pregnancy can result in lower birth weight as well as deformities in the fetus.[18][19] Smoking nearly doubles the risk of low birthweight babies. In 2004, 11.9% of babies born to smokers had low birthweight as compared to only 7.2% of babies born to nonsmokers. More specifically, infants born to smokers weigh on average 200 grams less than infants born to people who do not smoke.[20]

The nicotine in cigarette smoke constricts the blood vessels in the placenta and carbon monoxide, which is poisonous, enters the fetus' bloodstream, replacing some of the valuable oxygen molecules carried by hemoglobin in the red blood cells. Moreover, because the fetus cannot breathe the smoke out, it has to wait for the placenta to clear it. These effects account for the fact that, on average, babies born to smoking mothers are usually born too early and have a low birth weight (less than 2.5 kilograms or 5.5 pounds), making it more likely the baby will become ill or die. [21]

Premature and low birth weight babies face an increased risk of serious health problems as newborns have chronic lifelong disabilities such as cerebral palsy (a set of motor conditions causing physical disabilities), intellectual disabilities and learning problems.

Sudden infant death syndrome

Sudden infant death syndrome (SIDS) is the sudden death of an infant that is unexplainable by the infant's history. The death also remains unexplainable upon autopsy. Infants exposed to smoke, both during pregnancy and after birth, are found to be more at risk of SIDS due to the increased levels of nicotine often found in SIDS cases. Infants exposed to smoke during pregnancy are up to three times more likely to die of SIDS than children born to non-smoking mothers. [22]

Other birth defects

Birth defects associated with smoking during pregnancy[23]
DefectOdds ratio
cardiovascular/heart defects1.09
musculoskeletal defect1.16
limb reduction defects1.26
missing/extra digits1.18
clubfoot1.28
craniosynostosis1.33
facial defects1.19
eye defects1.25
orofacial clefts1.28
gastrointestinal defects1.27
gastroschisis1.50
anal atresia1.20
hernia1.40
undescended testes1.13
hypospadias0.90
skin defects0.82

Smoking can also cause other birth defects, reduced head circumference, altered brainstem development, altered lung structure, and cerebral palsy. Recently the U.S. Public Health Service reported that if all pregnant women in the United States stopped smoking, there would be an estimated 11% reduction in stillbirths and a 5% reduction in newborn deaths.[20]

Future obesity

A recent study has proposed that maternal smoking during pregnancy can lead to future teenage obesity. While no significant differences could be found between young teenagers with smoking mothers as compared to young teenagers with nonsmoking mothers, older teenagers with smoking mothers were found to have on average 26% more body fat and 33% more abdominal fat than similar aged teenagers with non-smoking mothers. This increase in body fat may result from the effects of smoking during pregnancy, which is thought to impact fetal genetic programming in relation to obesity. While the exact mechanism for this difference is currently unknown, studies conducted on animals have indicated that nicotine may affect brain functions that deal with eating impulses and energy metabolism. These differences appear to have a significant effect on the maintenance of a healthy, normal weight. As a result of this alteration to brain function, teenage obesity can in turn lead to a variety of health problems including diabetes (a condition in which the affected individual's blood glucose level is too high and the body is unable to regulate it), hypertension (high blood pressure), and cardiovascular disease (any condition related to the heart but most commonly the thickening of arteries due to excess fat build-up).[24]

Quitting during pregnancy

According to a 2010 study published in the European Journal of Pediatrics, the cessation of maternal smoking during any point during pregnancy reduces the risk of negative pregnancy outcomes when compared to smoking throughout the entire nine months of pregnancy, especially if it is done within the first trimester. The study found that expectant mothers who smoke at any time during the first trimester increase the risk that their child will develop birth defects, particularly congenital heart defects than expectant mothers who have never smoked. The study found that the risk posed to the expectant mother's child increases both with the quantity of cigarettes smoked, as well as the length of time during pregnancy during which the mother continues to smoke. This, per the study, renders a more positive outcome for women who cease smoking for the remainder of their pregnancy relative to women who continue to smoke.[13]

There are many resources to help pregnant women quit smoking such as counseling and drug therapies. For non-pregnant smokers, an often-recommended aid to quitting smoking is through the use of nicotine replacement therapy (NRT) in the form of patches, gum, inhalers, lozenges, sprays or sublingual tablets. NRT, however, delivers nicotine to the expectant mother's child in utero. For some pregnant smokers, NRT might still be the most beneficial and helpful solution to quit smoking. Research in the UK has also shown that e-cigarettes could be more effective than nicotine patches, and because of this, could lead to better pregnancy outcomes.[25][26] It is important that smokers talk to doctor to determine the best course of action on an individual basis.[27]

Smoking after pregnancy

Infants exposed to smoke, both during pregnancy and after birth, are found to be more at risk of sudden infant death syndrome (SIDS).[22]

Breastfeeding

If one does continue to smoke after giving birth, however, it is still more beneficial to breastfeed than to completely avoid this practice altogether. There is evidence that breastfeeding offers protection against many infectious diseases, especially diarrhea. Even in babies exposed to the harmful effects of nicotine through breast milk, the likelihood of acute respiratory illness is significantly diminished when compared to infants whose mothers smoked but were formula fed.[28] Regardless, the benefits of breastfeeding outweigh the risks of nicotine exposure.

Passive smoking

Passive smoking is associated with many risks to children, including, sudden infant death syndrome (SIDS),[29][30] asthma,[31][32] lung infections,[33][34][35][36] impaired respiratory function and slowed lung growth,[10] Crohn's disease,[37] learning difficulties and neurobehavioral effects,[38][39] an increase in tooth decay,[40] and an increased risk of middle ear infections.[41][42][1]

Multigenerational effect

A grandmother who smokes during her daughter's pregnancy transmits an increased risk of asthma to her grandchildren, even if the second-generation mother does not smoke.[43] The multigenerational epigenetic effect of nicotine on lung function has already been demonstrated.[43]

See also

References

  1. 1 2 Avşar TS, McLeod H, Jackson L (March 2021). "Health outcomes of smoking during pregnancy and the postpartum period: an umbrella review". BMC Pregnancy and Childbirth. 21 (1): 254. doi:10.1186/s12884-021-03729-1. PMC 7995767. PMID 33771100.
  2. ↑ Ness RB, Grisso JA, Hirschinger N, Markovic N, Shaw LM, Day NL, Kline J (February 1999). "Cocaine and tobacco use and the risk of spontaneous abortion". The New England Journal of Medicine. 340 (5): 333–339. doi:10.1056/NEJM199902043400501. PMID 9929522.
  3. ↑ Oncken C, Kranzler H, O'Malley P, Gendreau P, Campbell WA (May 2002). "The effect of cigarette smoking on fetal heart rate characteristics". Obstetrics and Gynecology. 99 (5 Pt 1): 751–755. doi:10.1016/S0029-7844(02)01948-8. PMID 11978283. S2CID 38760373.
  4. ↑ Najdawi F, Faouri M (May 1999). "Maternal smoking and breastfeeding". Eastern Mediterranean Health Journal. 5 (3): 450–456. doi:10.26719/1999.5.3.450. PMID 10793823. S2CID 30513271.
  5. ↑ McDonough M (August 2015). "Update on medicines for smoking cessation". Australian Prescriber. 38 (4): 106–111. doi:10.18773/austprescr.2015.038. PMC 4653977. PMID 26648633.
  6. 1 2 3 Castles A, Adams EK, Melvin CL, Kelsch C, Boulton ML (April 1999). "Effects of smoking during pregnancy. Five meta-analyses". American Journal of Preventive Medicine. 16 (3): 208–215. doi:10.1016/S0749-3797(98)00089-0. PMID 10198660. S2CID 33535194.
  7. ↑ "Substance Use During Pregnancy | CDC". 16 July 2020. Archived from the original on 18 December 2022. Retrieved 12 September 2017.
  8. ↑ "Preventing Smoking and Exposure to Secondhand Smoke Before, During, and After Pregnancy" (PDF). Preventing Smoking and Exposure to Secondhand Smoke Before, During, and After Pregnancy. CDC, Department of Health and Human Services. Retrieved 22 September 2016.
  9. ↑ Eisenberg L, Brown SH (1995). The best intentions: unintended pregnancy and the well-being of children and families. Washington, D.C: National Academy Press. pp. 68–70. ISBN 978-0-309-05230-6.
  10. 1 2 Centers for Disease Control and Prevention. 2007. Preventing Smoking and Exposure to Secondhand Smoke Before, During, and After Pregnancy Archived 11 September 2011 at the Wayback Machine.
  11. ↑ MedlinePlus Encyclopedia: Placenta previa
  12. ↑ Anderka M, Romitti PA, Sun L, Druschel C, Carmichael S, Shaw G (2010). "Patterns of tobacco exposure before and during pregnancy". Acta Obstetricia et Gynecologica Scandinavica. 89 (4): 505–514. doi:10.3109/00016341003692261. PMC 6042858. PMID 20367429.
  13. 1 2 Vardavas CI, Chatzi L, Patelarou E, Plana E, Sarri K, Kafatos A, et al. (June 2010). "Smoking and smoking cessation during early pregnancy and its effect on adverse pregnancy outcomes and fetal growth". European Journal of Pediatrics. 169 (6): 741–748. doi:10.1007/s00431-009-1107-9. PMID 19953266. S2CID 20429746.
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  15. ↑ Krotz S, Fajardo J, Ghandi S, Patel A, Keith LG (February 2002). "Hypertensive disease in twin pregnancies: a review". Twin Research. 5 (1): 8–14. doi:10.1375/1369052022848. PMID 11893276.
  16. ↑ E. (n.d.). Maternal Smoking Could Lead to an Increased Risk for Tourette Syndrome and Tic Disorders. Retrieved from https://www.elsevier.com/about/press-releases/research-and-journals/maternal-smoking-could-lead-to-an-increased-risk-for-tourette-syndrome-and-tic-disorders Archived 18 December 2022 at the Wayback Machine
  17. ↑ Fell M, Dack K, Chummun S, Sandy J, Wren Y, Lewis S (September 2022). "Maternal Cigarette Smoking and Cleft Lip and Palate: A Systematic Review and Meta-Analysis". The Cleft Palate-Craniofacial Journal. 59 (9): 1185–1200. doi:10.1177/10556656211040015. PMC 9411693. PMID 34569861. S2CID 237943233.
  18. ↑ "[Infographic] 12 Do's and Don'ts of Pregnancy". Pregnancy Savvy. Archived from the original on 27 August 2016. Retrieved 25 August 2016.
  19. ↑ "Smoking During Pregnancy". Center of Disease Control and Prevention. 29 May 2019. Archived from the original on 20 September 2020. Retrieved 19 September 2020.
  20. 1 2 "2004 Surgeon General's Report" (PDF). Chapter 5 Reproductive Effects. Center for Disease Control. Archived (PDF) from the original on 19 January 2017. Retrieved 22 September 2016.
  21. ↑ Engebretson, Joan (2013). Materinity Nursing Care. Canada: Nelson Education, Ltd. p. 417. ISBN 978-1-111-54311-2. Archived from the original on 29 October 2016.
  22. 1 2 Bajanowski T, Brinkmann B, Mitchell EA, Vennemann MM, Leukel HW, Larsch KP, Beike J (January 2008). "Nicotine and cotinine in infants dying from sudden infant death syndrome". International Journal of Legal Medicine. 122 (1): 23–28. doi:10.1007/s00414-007-0155-9. PMID 17285322. S2CID 26325523.
  23. ↑ Unless else specified in table, then reference is: Hackshaw A, Rodeck C, Boniface S (2011). "Maternal smoking in pregnancy and birth defects: a systematic review based on 173 687 malformed cases and 11.7 million controls". Human Reproduction Update. 17 (5): 589–604. doi:10.1093/humupd/dmr022. PMC 3156888. PMID 21747128.
  24. ↑ "Maternal Smoking during Pregnancy and Childhood Obesity". Archived from the original on 4 November 2016. Retrieved 6 November 2016.
  25. ↑ Beeston, Amelia (4 November 2022). "Is vaping better than nicotine patches during pregnancy?". NIHR Evidence. doi:10.3310/nihrevidence_54425. S2CID 253360129. Archived from the original on 11 November 2022. Retrieved 4 November 2022.
  26. ↑ Hajek P, Przulj D, Pesola F, Griffiths C, Walton R, McRobbie H, et al. (May 2022). "Electronic cigarettes versus nicotine patches for smoking cessation in pregnancy: a randomized controlled trial". Nature Medicine. 28 (5): 958–964. doi:10.1038/s41591-022-01808-0. PMC 9117131. PMID 35577966.
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  29. ↑ McMartin KI, Platt MS, Hackman R, Klein J, Smialek JE, Vigorito R, Koren G (February 2002). "Lung tissue concentrations of nicotine in sudden infant death syndrome (SIDS)". The Journal of Pediatrics. 140 (2): 205–209. doi:10.1067/mpd.2002.121937. PMID 11865272.
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  31. ↑ Surgeon General 2006, pp. 311–9
  32. ↑ Vork KL, Broadwin RL, Blaisdell RJ (October 2007). "Developing asthma in childhood from exposure to secondhand tobacco smoke: insights from a meta-regression". Environmental Health Perspectives. 115 (10): 1394–1400. doi:10.1289/ehp.10155. PMC 2022647. PMID 17938726.
  33. ↑ Spencer N, Coe C (July 2003). "Parent reported longstanding health problems in early childhood: a cohort study". Archives of Disease in Childhood. 88 (7): 570–573. doi:10.1136/adc.88.7.570. PMC 1763148. PMID 12818898.
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  36. ↑ DiFranza JR, Aligne CA, Weitzman M (April 2004). "Prenatal and postnatal environmental tobacco smoke exposure and children's health". Pediatrics. 113 (4 Suppl): 1007–1015. doi:10.1542/peds.113.S3.1007. PMID 15060193. S2CID 248349.
  37. ↑ Mahid SS, Minor KS, Stromberg AJ, Galandiuk S (April 2007). "Active and passive smoking in childhood is related to the development of inflammatory bowel disease". Inflammatory Bowel Diseases. 13 (4): 431–438. doi:10.1002/ibd.20070. PMID 17206676. S2CID 46428261.
  38. ↑ Richards GA, Terblanche AP, Theron AJ, Opperman L, Crowther G, Myer MS, et al. (February 1996). "Health effects of passive smoking in adolescent children". South African Medical Journal = Suid-Afrikaanse Tydskrif vir Geneeskunde. 86 (2): 143–147. PMID 8619139.
  39. ↑ Scientific Consensus Statement on Environmental Agents Associated with Neurodevelopmental Disorders Archived 27 March 2009 at the Wayback Machine, The Collaborative on Health and the Environment's Learning and Developmental Disabilities Initiative, 7 November 2007
  40. ↑ Avşar A, Darka O, Topaloğlu B, Bek Y (October 2008). "Association of passive smoking with caries and related salivary biomarkers in young children". Archives of Oral Biology. 53 (10): 969–974. doi:10.1016/j.archoralbio.2008.05.007. PMID 18672230.
  41. ↑ Surgeon General 2006, pp. 293–309
  42. ↑ Jacoby PA, Coates HL, Arumugaswamy A, Elsbury D, Stokes A, Monck R, et al. (May 2008). "The effect of passive smoking on the risk of otitis media in Aboriginal and non-Aboriginal children in the Kalgoorlie-Boulder region of Western Australia". The Medical Journal of Australia. 188 (10): 599–603. doi:10.5694/j.1326-5377.2008.tb01801.x. PMID 18484936. S2CID 9420655.
  43. 1 2 Chatkin JM, Dullius CR (2016). "The management of asthmatic smokers". Asthma Research and Practice. 2 (1): 10. doi:10.1186/s40733-016-0025-7. PMC 5142412. PMID 27965778. This article incorporates text available under the CC BY 4.0 license.
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