Thrombospondin 3

THBS3
Identifiers
Aliases	THBS3, TSP3, thrombospondin 3
External IDs	OMIM: 188062 MGI: 98739 HomoloGene: 5159 GeneCards: THBS3
Gene location (Human)
Chr.	Chromosome 1 (human)
End	155,209,051 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	89,134,144 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; tibia; ; right coronary artery; ; left uterine tube; ; tibial nerve; ; canal of the cervix; ; ascending aorta; ; left coronary artery; ; anterior pituitary; ; gastric mucosa;
	Top expressed in
	spermatocyte; ; lip; ; ankle; ; right lung lobe; ; ankle joint; ; esophagus; ; spermatid; ; uterus; ; belly cord; ; superior frontal gyrus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; heparin binding; extracellular matrix structural constituent;
Cellular component	perinuclear region of cytoplasm; extracellular region; extracellular matrix; extracellular space; collagen-containing extracellular matrix;
Biological process	growth plate cartilage development; ossification involved in bone maturation; cell-matrix adhesion; cell adhesion; bone trabecula formation; extracellular matrix organization;
	Sources:Amigo / QuickGO
Orthologs
	7059
	21827
	ENSG00000169231
	ENSMUSG00000028047
	P49746
	Q05895
	NM_001252607; NM_001252608; NM_007112
	NM_013691
	NP_001239536; NP_001239537; NP_009043
	NP_038719
	Wikidata
View/Edit Human	View/Edit Mouse

Thrombospondin-3 (TSP3) is a protein that in humans is encoded by the THBS3 gene.^[5]^[6]

The protein encoded by this gene belongs to the thrombospondin family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. TSP3 has been found to be involved in the regulation of skeletal maturation.^[7] This protein forms a pentameric molecule linked by a single disulfide bond. This gene shares a common promoter with metaxin 1.^[6] Identified as the gene on chromosome 1 responsible for mediating an associated with genetic susceptibility to SARS-CoV-2 infection.^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000169231 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028047 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Vos HL, Devarayalu S, de Vries Y, Bornstein P (Jul 1992). "Thrombospondin 3 (Thbs3), a new member of the thrombospondin gene family". J Biol Chem. 267 (17): 12192–6. doi:10.1016/S0021-9258(19)49823-2. PMID 1601886.
1 2 "Entrez Gene: THBS3 thrombospondin 3".
↑ Hankenson, Kurt (July 2005). "Mice with a Disruption of the Thrombospondin 3 Gene Differ in Geometric and Biomechanical Properties of Bone and Have Accelerated Development of the Femoral Head". Molecular and Cellular Biology. 25 (13): 5599–5606. doi:10.1128/MCB.25.13.5599-5606.2005. PMC 1156967. PMID 15964815.
↑ Niemi, Mari E. K.; et al. (July 2021). "Mapping the human genetic architecture of COVID-19". Nature. 600 (7889): 472–477. doi:10.1038/s41586-021-03767-x. PMC 8674144. PMID 34237774. S2CID 235776838.

O'Rourke KM, Laherty CD, Dixit VM (1993). "Thrombospondin 1 and thrombospondin 2 are expressed as both homo- and heterotrimers". J. Biol. Chem. 267 (35): 24921–4. doi:10.1016/S0021-9258(19)73983-0. PMID 1459996.
Adolph KW, Long GL, Winfield S, et al. (1995). "Structure and organization of the human thrombospondin 3 gene (THBS3)". Genomics. 27 (2): 329–36. doi:10.1006/geno.1995.1050. PMID 7558000.
Qabar A, Derick L, Lawler J, Dixit V (1995). "Thrombospondin 3 is a pentameric molecule held together by interchain disulfide linkage involving two cysteine residues". J. Biol. Chem. 270 (21): 12725–9. doi:10.1074/jbc.270.21.12725. PMID 7759526.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Qabar AN, Lin Z, Wolf FW, et al. (1994). "Thrombospondin 3 is a developmentally regulated heparin binding protein". J. Biol. Chem. 269 (2): 1262–9. doi:10.1016/S0021-9258(17)42252-6. PMID 8288588.
Bornstein P, Devarayalu S, Edelhoff S, Disteche CM (1993). "Isolation and characterization of the mouse thrombospondin 3 (Thbs3) gene". Genomics. 15 (3): 607–13. doi:10.1006/geno.1993.1114. PMID 8468055.
Winfield SL, Tayebi N, Martin BM, et al. (1997). "Identification of three additional genes contiguous to the glucocerebrosidase locus on chromosome 1q21: implications for Gaucher disease". Genome Res. 7 (10): 1020–6. doi:10.1101/gr.7.10.1020. PMC 310674. PMID 9331372.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Adolph KW (1999). "Relative abundance of thrombospondin 2 and thrombospondin 3 mRNAs in human tissues". Biochem. Biophys. Res. Commun. 258 (3): 792–6. doi:10.1006/bbrc.1999.0710. PMID 10329465.
Adolph KW, Bornstein P (2000). "The human thrombospondin 3 gene: analysis of transcription initiation and an alternatively spliced transcript". Mol. Cell Biol. Res. Commun. 2 (1): 47–52. doi:10.1006/mcbr.1999.0148. PMID 10527891.
Carron JA, Hiscott P, Hagan S, et al. (2001). "Cultured human retinal pigment epithelial cells differentially express thrombospondin-1, -2, -3, and -4". Int. J. Biochem. Cell Biol. 32 (11–12): 1137–42. doi:10.1016/S1357-2725(00)00065-0. PMID 11137453.
Armstrong DJ, Hiscott P, Batterbury M, Kaye S (2002). "Corneal stromal cells (keratocytes) express thrombospondins 2 and 3 in wound repair phenotype". Int. J. Biochem. Cell Biol. 34 (6): 588–93. doi:10.1016/S1357-2725(01)00157-1. PMID 11943589.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Dalla-Torre CA, Yoshimoto M, Lee CH, et al. (2006). "Effects of THBS3, SPARC and SPP1 expression on biological behavior and survival in patients with osteosarcoma". BMC Cancer. 6: 237. doi:10.1186/1471-2407-6-237. PMC 1609181. PMID 17022822.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000169231 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028047 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1601886-5] Vos HL, Devarayalu S, de Vries Y, Bornstein P (Jul 1992). "Thrombospondin 3 (Thbs3), a new member of the thrombospondin gene family". J Biol Chem. 267 (17): 12192–6. doi:10.1016/S0021-9258(19)49823-2. PMID 1601886.

[entrez-6] 1 2 "Entrez Gene: THBS3 thrombospondin 3".

[7] Hankenson, Kurt (July 2005). "Mice with a Disruption of the Thrombospondin 3 Gene Differ in Geometric and Biomechanical Properties of Bone and Have Accelerated Development of the Femoral Head". Molecular and Cellular Biology. 25 (13): 5599–5606. doi:10.1128/MCB.25.13.5599-5606.2005. PMC 1156967. PMID 15964815.

[8] Niemi, Mari E. K.; et al. (July 2021). "Mapping the human genetic architecture of COVID-19". Nature. 600 (7889): 472–477. doi:10.1038/s41586-021-03767-x. PMC 8674144. PMID 34237774. S2CID 235776838.

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References

Further reading