U&I (e.g. You and I) may refer to:
- U&I (album), by Leila, 2012
- "U&I" (song), by Ailee, 2013
- "U&I", a song by Jodeci from their album Forever My Lady
- "Ü&I", a song by Lykke Li from her album Eyeye
- U and I: A True Story, a 1991 book by Nicholson Baker
- Utah-Idaho Sugar Company, an American sugar beet processing company
- Upin & Ipin, a Malaysian TV Series
See also
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