Vogelstein is the surname of:
- Bert Vogelstein (born 1949), an American Howard Hughes Medical Institute investigator at The Johns Hopkins University
- Carl Christian Vogel von Vogelstein (1788–1868), German painter
- Rabbi Heinemann Vogelstein (1841–1911), German liberal rabbi
- Rabbi Hermann Vogelstein (1870–1942), German-American historian, liberal rabbi
- Ludwig Vogelstein (1871–1934), German-American industrialist and philanthropist
- Theodor Vogelstein (1880–1957), banker and industrialist
- Julie Braun-Vogelstein (1883–1971), German-American art historian, author, editor, and journalist
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