Wolfsbane may refer to:
Plants
- Aconitum, a genus of toxic flowering plants of the northern hemisphere
- Aconitum lycoctonum or northern wolfsbane
- Arnica montana, a toxic European flowering plant
Arts and entertainment
- Wolfsbane (band), an English heavy metal/hard rock band
- Wolfsbane (album), 1994
- Wolfsbane (character), a Marvel Comics superhero
- Wolfsbane (novel), a 2003 Doctor Who novel by Jacqueline Rayner
- Wolfbane (novel), a 1959 novel by Frederik Pohl and C. M. Kornbluth
- Wolfbane, a 2022 novel by Michelle Paver
- Wolfsbane, a 1978 novel by Craig Thomas
- Wolf's Bane, a 1993 fantasy book set in the Lone Wolf universe
- Sir Peter Wolf's-Bane, a title Aslan gives to Peter Pevensie in C. S. Lewis' The Lion, the Witch and the Wardrobe novel after he kills Maugrim, a talking wolf
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