YSS is Young–Simpson syndrome, a rare congenital disorder.
YSS may also refer to:
- Yogoda Satsanga Society of India, a non-profit nonsectarian spiritual organization
- Yorkshire Subterranean Society, a caving club
- Young Scottish Socialists, the youth wing of the Scottish Socialist Party
- Yengema Secondary School, Sierra Leone
- Yishun Secondary School, Singapore
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