2018 Winston-Salem Open
DateAugust 19–25
Edition50th
CategoryATP World Tour 250 Series
Draw48S / 16D
SurfaceHard / outdoor
LocationWinston-Salem, North Carolina, U.S.
VenueWake Forest University
Champions
Singles
Russia Daniil Medvedev
Doubles
Netherlands Jean-Julien Rojer / Romania Horia Tecău

The 2018 Winston-Salem Open was a men's tennis tournament played on outdoor hard courts. It was the 50th edition of the Winston-Salem Open (as successor to previous tournaments in New Haven and Long Island), and part of the ATP World Tour 250 Series of the 2018 ATP World Tour. It took place at Wake Forest University in Winston-Salem, North Carolina, United States, from August 19 through August 25, 2018. It was the last event on the 2018 US Open Series before the 2018 US Open.

Singles main-draw entrants

Seeds

Country Player Rank* Seed
 BEL David Goffin 11 1
 ESP Pablo Carreño Busta 13 2
 GBR Kyle Edmund 16 3
 ITA Marco Cecchinato 22 4
 BIH Damir Džumhur 24 5
 KOR Chung Hyeon 25 6
 SRB Filip Krajinović 31 7
 USA Steve Johnson 33 8
 USA Sam Querrey 34 9
 GEO Nikoloz Basilashvili 36 10
 RUS Andrey Rublev 37 11
 FRA Gilles Simon 40 12
 ESP Albert Ramos Viñolas 41 13
 CHI Nicolás Jarry 42 14
 AUS Alex de Minaur 43 15
 GER Peter Gojowczyk 47 16

* Rankings are as of August 13, 2018

Other entrants

The following players received wildcards into the singles main draw:

The following players received entry from the qualifying draw:

The following players received entry as lucky losers:

Withdrawals

Before the tournament
During the tournament

Doubles main-draw entrants

Seeds

Country Player Country Player Rank1 Seed
 POL Łukasz Kubot  BRA Marcelo Melo 23 1
 NED Jean-Julien Rojer  ROU Horia Tecău 25 2
 JPN Ben McLachlan  GER Jan-Lennard Struff 53 3
 CHI Julio Peralta  ARG Horacio Zeballos 64 4
  • Rankings are as of August 13, 2018

Other entrants

The following pairs received wildcards into the doubles main draw:

The following pair received entry as alternates:

Withdrawals

Before the tournament

Champions

Singles

Doubles

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