Singles
2021 LTP Charleston Pro Tennis II
Champion	Despina Papamichail
Runner-up	Gabriela Cé
Score	1–6, 6–3, 6–3

Caroline Dolehide was the defending champion, having won the previous edition in 2019,^[1] however she chose to participate in qualifying for Wimbledon instead.

Despina Papamichail won the title, defeating Gabriela Cé in the final, 1–6, 6–3, 6–3.

Seeds

Draw

Finals

	Semifinals							Final
		Sofia Shapatava	3	0
	6	Gabriela Cé	6	6
								6	Gabriela Cé	6	3	3
								2	Despina Papamichail	1	6	6
		Fernanda Contreras	2	2
	2	Despina Papamichail	6	6

Top half

	First round							Second round							Quarterfinals							Semifinals
	1	C Perrin	4	63
	Q	Q Gleason	6	77				Q	Q Gleason	6	62	2
		S Shapatava	6	5	6				S Shapatava	0	77	6
		N Hanatani	4	7	1											S Shapatava	2	6	6
	PR	S Xu	3	4												S Chang	6	4	2
		S Chang	6	6					S Chang	6	6
	Q	L Chirico	6	7				Q	L Chirico	2	2
	7	M Zacarías	1	5																			S Shapatava	3	0
	3	H Chang	77	6																		6	G Cé	6	6
	SE	P Stearns	63	4				3	H Chang	6	3	2
		AS Sánchez	6	4	7				AS Sánchez	2	6	6
		ML Carlé	2	6	5											AS Sánchez	4	2
		M Mateas	6	0	713										6	G Cé	6	6
		K Stewart	4	6	611				M Mateas	1	4
	Q	M Sanchez	0	2				6	G Cé	6	6
	6	G Cé	6	6

Bottom half

	First round							Second round							Quarterfinals							Semifinals
	5	K Okamura	3	69
		F Stollár	6	711					F Stollár	0r
	Q	G Topalova	4	2				WC	E Navarro	5
	WC	E Navarro	6	6											WC	E Navarro	4	4
	WC	E Kalieva	0	4												F Contreras	6	6
		F Contreras	6	6					F Contreras	6	6
	WC	E Yu	3	6	3			4	A Parks	3	3
	4	A Parks	6	3	6																		F Contreras	2	2
	8	A Glatch	6	2	7																	2	D Papamichail	6	6
	Q	E Sema	2	6	5			8	A Glatch	6	4	6
	Q	P Hourigan	6	64	1			Q	E Davis	4	6	1
	Q	E Davis	4	77	6										8	A Glatch	6	0	4
	WC	T Ng	3	0											2	D Papamichail	4	6	6
	Q	C Chavatipon	6	6				Q	C Chavatipon	3	3
		A Sutjiadi	6	3	1			2	D Papamichail	6	6
	2	D Papamichail	2	6	6

References

• Main Draw