Bianchini is an Italian surname. Notable people with the surname include:
- Angela Bianchini (1921–2018), Italian fiction writer and literary critic
 - Brian Bianchini (1978–2004), American male model
 - Francesco Bianchini (1662–1729), Italian philosopher and scientist, after whom Bianchini (lunar crater) and Bianchini (Martian crater) are named
 - Frank Bianchini (born 1961), American football player
 - Gina Bianchini, founder of the Ning social networking platform
 - Giovanni Bianchini (1410–c.1449), Italian astronomer
 - Giuseppe Bianchini (1704–1764), Italian Oratorian, biblical, historical, and liturgical scholar
 - Leslie Bianchini (born 1947), Playboy magazine Playmate of the Month
 - Lorenzo Bianchini (born 1989), Italian professional football player
 - Orlando Bianchini (born 1955), Italian hammer thrower
 - Stefano Bianchini (born 1970), Italian mathematician
 - Vincenzo Bianchini (1903–2000), Italian artist
 - Victor Bianchini (born 1938), American judge
 
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