Desmethylcitalopram

Desmethylcitalopram
Clinical data
ATC code	none;
Legal status
Legal status	In general: uncontrolled;
Pharmacokinetic data
Elimination half-life	50 h
Identifiers
	IUPAC name (RS/S)-1-[3-(Methylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile;
CAS Number	62498-67-3 ;
PubChem CID	162180;
ChemSpider	142424 ;
UNII	3KBX9104IR;
CompTox Dashboard (EPA)	DTXSID90881082 ;
ECHA InfoCard	100.057.776
Chemical and physical data
Formula	C19H19FN2O
Molar mass	310.372 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CNCCCC1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F;
	InChI InChI=1S/C19H19FN2O/c1-22-10-2-9-19(16-4-6-17(20)7-5-16)18-8-3-14(12-21)11-15(18)13-23-19/h3-8,11,22H,2,9-10,13H2,1H3 ; Key:PTJADDMMFYXMMG-UHFFFAOYSA-N ;
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Desmethylcitalopram is an active metabolite of the antidepressant drugs citalopram (racemic) and escitalopram (the S-enantiomer, which would be called desmethylescitalopram).^[1]^[2] Like citalopram and escitalopram, desmethylcitalopram functions as a selective serotonin reuptake inhibitor (SSRI), and is responsible for some of its parents' therapeutic benefits.

References

↑ "Desmethylcitalopram". Human Metabolome Database.
↑ Brøsen K, Naranjo CA (August 2001). "Review of pharmacokinetic and pharmacodynamic interaction studies with citalopram". European Neuropsychopharmacology. 11 (4): 275–83. doi:10.1016/s0924-977x(01)00101-8. PMID 11532381. S2CID 11837037.

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