This is a list of airlines which have an air operator's certificate issued by the Federal Aviation Administration of the United States.

Note: Destinations in bold indicate primary hubs, those in italic indicate secondary hubs, and those with regular font indicate focus cities. For legacy carriers American, Delta, and United, the most strategic/well connected hubs are shown as Primary Hubs.

Passenger airlines

Mainline

Airline	Image	IATA	ICAO	Callsign	Primary hubs, secondary hubs	Founded	Notes
Alaska Airlines		AS	ASA	ALASKA	Seattle/Tacoma Anchorage Portland (OR) San Francisco Los Angeles	1932	Founded as McGee Airways and commenced operations in 1944 as Alaska Airlines.
Allegiant Air		G4	AAY	ALLEGIANT	Las Vegas Cincinnati Fort Walton Beach Indianapolis Orlando/Sanford Memphis Pittsburgh Bellingham Des Moines Punta Gorda Grand Rapids	1997	Founded as WestJet Express and began operations in 1998 as Allegiant Air.
American Airlines		AA	AAL	AMERICAN	Dallas/Fort Worth Charlotte Chicago-O'Hare Los Angeles Miami New York-JFK New York-LaGuardia Philadelphia Phoenix-Sky Harbor Washington-National	1926	Founded as American Airways and commenced operations in 1936 as American Air Lines; largest airline in the world based on airline company revenue, scheduled passenger miles flown (per year), and fleet size.
Avelo Airlines		XP	VXP	AVELO	Burbank New Haven Orlando Raleigh/Durham Wilmington Airport (Delaware)	1987	First did business as Casino Express Airlines and commenced operations in 1989. Started scheduled service in Burbank, CA, April 28, 2021.
Breeze Airways		MX	MXY	MOXY	Charleston Hartford New Orleans Norfolk Providence Provo Tampa	2018	Founded as Moxy Airways but was renamed due to copyright issues
Delta Air Lines		DL	DAL	DELTA	Atlanta Boston Detroit Los Angeles Minneapolis/St. Paul New York-JFK New York-LaGuardia Salt Lake City Seattle/Tacoma	1924	Founded as Huff Daland Dusters and commenced operations in 1929 as Delta Air Service.
Eastern Airlines		2D	EAL	EASTERN	Miami	2010
Frontier Airlines		F9	FFT	FRONTIER FLIGHT	Denver Atlanta Chicago-O'Hare Cincinnati Cleveland Las Vegas Miami Orlando Philadelphia Raleigh/Durham	1994
Hawaiian Airlines		HA	HAL	HAWAIIAN	Honolulu Kahului	1929	Founded as Inter-Island Airways in early 1929 and commenced operations in late 1929 as Hawaiian Airlines
JetBlue		B6	JBU	JETBLUE	New York-JFK Boston Los Angeles Fort Lauderdale Orlando	1998	Founded as New Air and commenced operations in 2000 as JetBlue Airways.
New Pacific Airlines		7H	RVF	RAVN FLIGHT	Ontario	2021	Founded as Northern Pacific Airways.
Southwest Airlines		WN	SWA	SOUTHWEST	Dallas-Love Atlanta Baltimore Chicago-Midway Denver Houston-Hobby Las Vegas Los Angeles Oakland Orlando Phoenix-Sky Harbor Nashville	1967	Founded as Air Southwest and commenced operations in 1971 as Southwest Airlines; largest airline in the world based on number of passengers served per year.
Spirit Airlines		NK	NKS	SPIRIT WINGS	Atlantic City Atlanta Detroit Las Vegas Fort Lauderdale Chicago-O'Hare Dallas/Fort Worth Baltimore Orlando Houston-Intercontinental	1980	Founded as Charter One.
Sun Country Airlines		SY	SCX	SUN COUNTRY	Minneapolis/St. Paul Dallas/Fort Worth Las Vegas	1982	Commenced operations in 1983. Operates some Amazon Air cargo flights.
United Airlines		UA	UAL	UNITED	Chicago-O'Hare Denver Guam Houston-Intercontinental Los Angeles Newark San Francisco Washington-Dulles	1926	Founded as Varney Air Lines and commenced operations in 1931 as United Air Lines.

Regional

Airline	Image	IATA	ICAO	Callsign	Primary hubs, secondary hubs	Founded	Notes
Air Wisconsin		ZW	AWI	WISCONSIN	Chicago-O'Hare Washington-Dulles	1965	Operates as American Eagle[1]
Cape Air		9K	KAP	CAIR	Hyannis Billings Boston Nantucket St. Louis San Juan Albany Martha's Vineyard	1988
CommutAir		C5	UCA	COMMUTAIR	Denver Newark Washington-Dulles	1989	Operates as United Express.
Contour Airlines		LF	VTE	VOLUNTEER	Smyrna (TN)	1982
Elite Airways		7Q	MNU	MAINER	Melbourne/Orlando Newark Portland (Maine)	2006	Commenced operations in 2014.
Endeavor Air		9E	EDV	ENDEAVOR	Minneapolis/St. Paul Atlanta Cincinnati Detroit New York-JFK New York-LaGuardia	1985	Founded as Express Airlines I. Operates as Delta Connection.
Envoy Air		MQ	ENY	ENVOY	Dallas/Fort Worth Chicago-O'Hare Miami	1984	Founded as American Eagle Airlines. Operates as American Eagle.
GoJet Airlines		G7	GJS	LINDBERGH	Chicago-O'Hare Denver	2004	Commenced operations in 2005. Operates as United Express.
Horizon Air		QX	QXE	HORIZON	Seattle/Tacoma Portland (OR)	1981	Operates as Alaska Airlines.
Mesa Airlines		YV	ASH	AIR SHUTTLE	Houston-Intercontinental Washington-Dulles	1980	Founded as Mesa Air Shuttle. All but one aircraft operated as United Express.
Piedmont Airlines		PT	PDT	PIEDMONT	Charlotte Philadelphia Washington-National	1961	Founded as Henson Aviation and commenced operations in 1962. Operates as American Eagle.
PSA Airlines		OH	JIA	BLUE STREAK	Charlotte Philadelphia Washington-National	1979	Founded as Vee Neal Airlines. Operates as American Eagle.
Republic Airways		YX	RPA	BRICKYARD	As American Eagle: Indianapolis Columbus (OH) Kansas City Miami New York-LaGuardia Philadelphia Pittsburgh Washington-National As United Express: Indianapolis Chicago-O'Hare Columbus (OH) Kansas City Newark New York-LaGuardia Pittsburgh Washington-National As Delta Connection: Indianapolis Chicago-O'Hare Columbus (OH) New York-LaGuardia	1998	Commenced operations in 2005. Operates as American Eagle, United Express and Delta Connection.
Silver Airways		3M	SIL	SILVER WINGS	Fort Lauderdale Orlando Tampa	2011
SkyWest Airlines		OO	SKW	SKYWEST	As Delta Connection: Atlanta Boise Colorado Springs Detroit Los Angeles Minneapolis/St. Paul Salt Lake City Seattle/Tacoma As United Express: Boise Colorado Springs Chicago-O'Hare Denver Houston-Bush Los Angeles San Francisco As American Eagle: Dallas-Ft Worth Chicago-O'Hare Los Angeles Phoenix-Sky Harbor As Alaska Airlines: Portland (OR) Seattle/Tacoma	1972	Operates as Delta Connection, United Express, American Eagle and Alaska Airlines.

Commuter

Airline	Image	IATA	ICAO	Callsign	Primary hubs, secondary hubs	Founded	Notes
Advanced Air		AN	WSN	WINGSPAN	Hawthorne	2005	Has the EAS contract to serve Grant County Airport (New Mexico).
Air Sunshine		YI	RSI	AIR SUNSHINE	San Juan	1982
Bering Air		8E	BRG	BERING AIR	Nome Kotzebue Unalakleet	1979
Boutique Air		4B	BTQ	BOUTIQUE	Dallas/Fort Worth Denver Phoenix-Sky Harbor	2007
Everts Air		5V	VTS	EVERTS	Fairbanks Anchorage	1978	Founded as Tatonduk Flying Service.
Gem Air					Salmon	2014
Grand Canyon Airlines		YR	CVU	CANYON VIEW	Boulder City Grand Canyon Page	1927	Founded as Scenic Airways.
Grand Canyon Scenic Airlines		YR	SCE	SCENIC	Grand Canyon	1967	Founded as Scenic Airlines.
Grant Aviation		GV	GUN	HOOT	Anchorage Bethel Cold Bay Dillingham Emmonak Kenai King Salmon Unalaska/Dutch Harbor	1971	Founded as Delta Air Services.
Griffing Flying Service					Port Clinton	1937
Island Airways					Charlevoix	1945	Founded as McPhillips Flying Service.
JSX		XE	JSX	BIGSTRIPE	Burbank Oakland Las Vegas Santa Ana Phoenix Concord	2016	Operator of Taos Air flights from 2022.
Kenmore Air		M5	KEN	KENMORE	Kenmore Seattle-Lake Union Seattle-Boeing	1946	Founded as Mines Collins Munro.
Key Lime Air		KG	LYM	KEY LIME	Denver-Centennial Denver Denver-Rocky Mountain Grand Junction	1997	Operates as Denver Air Connection.
Mokulele Airlines		MW	MHO	MAHALO	Kailua-Kona Kahului	1994	Founded as Mokulele Flight Service.
New England Airlines		EJ	NEA	NEW ENGLAND	Westerly	1970
Penobscot Island Air					Rockland	2004
Reliant Air			RLI	RELIANT	Danbury	1988
San Juan Airlines				SKYFERRY	Bellingham	2002
Servant Air		8D			Kodiak	2003
Southern Airways Express		9X	FDY	FRIENDLY	Memphis Destin Pittsburgh Washington-Dulles	2013
Surf Air			UF	SURFAIR	Hawthorne Oakland San Carlos Santa Barbara Truckee	2012
Tailwind Air		TQ	PGN	PEREGRINE		2014
Taquan Air		K3	TQN	TAQUAN	Ketchikan Harbor	1977
Tradewind Aviation		TJ	GPD	GOODSPEED	Oxford (CT) San Juan White Plains	2001
Ultimate Air Shuttle		UE	UJC	ULTIMATE	Cincinnati-Lunken	2009
Utah Airways					Ogden	2015
Warbelow's Air Ventures		4W	WAV	WARBELOW	Fairbanks	1958
Wright Air Service		8V	WRF	WRIGHT FLYER	Fairbanks	1966

Charter

Airline	Image	IATA	ICAO	Callsign	Primary hubs, secondary hubs	Founded	Notes
Air Charter Bahamas
Air Flight Charters			FLL		Fort Lauderdale	1987
Airshare			XSR	AIRSHARE		2000	Founded as Executive Flight Services
Berry Aviation			BYA	BERRY	San Marcos	1983
Bighorn Airways			BHR	BIGHORN AIR	Sheridan	1947
Charter Air Transport		VC	SRY	STINGRAY	Cleveland-Lakefront	1997
Choice Airways			CSX	CHOICE AIR	Fort Lauderdale-Executive	2009
ExcelAire			XLS	EXCELAIRE	Long Island/Islip	1993
Global Crossing Airlines		G6	GXA	GEMINI	Atlantic City Las Vegas Miami	2018
Gryphon Airlines		Y3	VOS
IAero Airways		WQ	SWQ	SWIFTFLIGHT	Miami	1997	Founded as Swift Air
IBC Airways		II	CSQ	CHASQUI	Fort Lauderdale	1991
L-3 Flight International Aviation			RTD	RIPTIDE	Newport News	1972
Liberty Jet Management			LRT	LIBERTY JET	Long Island/Islip	2006
NetJets		1I	EJA	EXECJET	Columbus	1964	Founded as Executive Jets Aviation.
Omni Air International		X9	OAE	OMNI-EXPRESS	Tulsa	1993
Omni Air Transport			DRL	DRILLER	Tulsa
Pacific Coast Jet			PXT	PACK COAST		2006
Pentastar Aviation			DCX	TANGO	Waterford	1964	Founded as Chrysler Air Transportation.
Phoenix Air			PHA	GRAY BIRD	Cartersville	1978
PlaneSense			CNS	CHRONOS	Portsmouth (NH)	1992
Presidential Airways			PRD	PRESIDENTIAL	Melbourne/Orlando
Sierra Pacific Airlines		SI	SPA	SIERRA PACIFIC	Tucson	1970	Commenced operations in 1971.
Skymax			SMX	SKYMAX	Fort Lauderdale	1997	Commenced operations in 2013.
Stampede Aviation					Healy/Denali NP	2011
Superior Air Charter			RSP	REDSTRIPE		2006
Superior Aviation		SO	HKA	SPEND AIR	Lansing	1979
Talkeetna Air Taxi					Talkeetna	1947	Founded as Talkeetna Flying Service.
Tropic Ocean Airways					Fort Lauderdale	2009
World Atlantic Airlines		K8	WAL	WORLD ATLANTIC	Miami	2002	Founded as Caribbean Sun Airlines and commenced operations in 2003.
XOJET Aviation LLC			XOJ	XOJET	Sacramento-McClellan	2006

Cargo airlines

Airline	Image	IATA	ICAO	Callsign	Primary hubs, secondary hubs	Founded	Notes
21 Air		2I	CSB	CARGO SOUTH	Greensboro	2014
ABX Air		GB	ABX	ABEX	Wilmington (OH) Cincinnati Miami	1980	Founded as Airborne Express. Operates some Amazon Air flights.
Air Cargo Carriers		2Q	SNC	NIGHT CARGO	Milwaukee Cincinnati	1986	Commenced operations in 1980.
AirNet Express			USC	STAR CHECK	Columbus-Rickenbacker	1974	Founded as Financial Air Express.
Air Transport International		8C	ATN	AIR TRANSPORT	Wilmington (OH) Cincinnati	1978	Founded as US Airways and commenced operations in 1980. Operates some Amazon Air flights.
Alaska Central Express		KO	AER	ACE AIR	Anchorage	1996
Aloha Air Cargo		KH	AAH	ALOHA	Honolulu	1946	Founded as Trans-Pacific Airlines and separated from now-defunct Aloha Airlines in 2008.
Alpine Air Express		5A	AIP	ALPINE AIR	Provo Billings Sioux Falls	1971
Amazon Air		AFW	KAFW	AMAZON AIR	Fort Worth/Alliance Cincinnati Leipzig/Halle San Bernardino Ontario Wilmington	2015	Formerly Amazon Prime Air
Ameriflight		A8	AMF	AMFLIGHT	Dallas/Fort Worth Burbank	1968	Founded as California Air Charter.
Amerijet International		M6	AJT	AMERIJET	Miami Port of Spain	1974
Ameristar Jet Charter		7Z	AJI	AMERISTAR	Dallas-Addison El Paso Willow Run	2000
Asia Pacific Airlines		P9	MGE	MAGELLAN	Guam Honolulu	1998
Atlas Air		5Y	GTI	GIANT	New York-JFK Anchorage Cincinnati Houston Huntsville Los Angeles Miami	1992	Commenced operations in 1993. Operates some Amazon Air flights.
Bemidji Airlines		CH	BMJ	BEMIDJI	Bemidji Minneapolis/St. Paul	1946	Commenced operations in 1947.
Castle Aviation			CSJ	CASTLE	Akron/Canton	1986
Corporate Air			CPT	AIRSPUR	Billings	1981
CSA Air			IRO	IRON AIR	Iron Mountain	1998
Empire Airlines		EM	CFS	EMPIRE	Coeur d' Alene Spokane	1977
Everts Air Cargo		5V	VTS	EVERTS	Fairbanks Anchorage	1995
FedEx Express		FX	FDX	FEDEX	Memphis Anchorage Cologne/Bonn Dubai Fort Worth Greensboro Guangzhou Indianapolis Miami Milan-Malpensa Newark Oakland Osaka-Kansai Paris-Charles de Gaulle Seoul-Incheon Toronto-Pearson	1971	Founded as Federal Express and commenced operations in 1973.
Freight Runners Express			FRG	FREIGHT RUNNERS	Milwaukee	1985
IFL Group		IF	IFL	EIFFEL	Waterford Miami	1983	Founded as Air Contract Cargo.
Kalitta Air		K4	CKS	CONNIE	Ypsilanti Anchorage Bahrain Cincinnati Hong Kong New York-JFK	1967	Founded as American International Airways.
Kalitta Charters		CB	KFS	KALITTA	Ypsilanti
Lynden Air Cargo		L2	LYC	LYNDEN	Anchorage	1995
Martinaire			MRA	MARTEX	Addison	1978
Merlin Airways			MEI	AVALON	Billings Miami San Juan	1983
Mountain Air Cargo		C2	MTN	MOUNTAIN	Kinston	1974
National Airlines		N8	NCR	NATIONAL CARGO	Orlando/Sanford	1985	Commenced operations in 1986.
Northern Air Cargo		NC	NAC	YUKON	Anchorage Miami	1956
Polar Air Cargo		PO	PAC	POLAR	Anchorage Cincinnati Hong Kong Honolulu Los Angeles Leipzig/Halle Seoul-Incheon Shanghai-Pudong Sharjah Sydney	1993
Royal Air Freight			RAX	AIR ROYAL	Waterford	1961
Ryan Air Services		7S	RYA	RYAN AIR	Anchorage Aniak Bethel Emmonak Kotzebue Nome St. Mary's Unalakleet	1953	Founded as Unalakleet Air Taxi.
Sky Lease Cargo		GG	KYE	SKY CUBE	Miami	1969	Founded as Wrangler Aviation and commenced operations in 1973.
Skyway Enterprises		KI	SKZ	SKYWAY-INC		1981	Commenced operations in 1983.
StratAir					Miami	2018	Virtual airline on behalf of Northern Air Cargo.
Trans Executive Airlines		KH	MUI	RHOADES EXPRESS	Honolulu	1982
UPS Airlines		5X	UPS	UPS	Louisville Chicago/Rockford Cologne/Bonn Columbia (SC) Dallas/Fort Worth Hamilton Hong Kong Kuala Lumpur Miami Ontario Philadelphia Shanghai-Pudong Shenzhen	1988
USA Jet Airlines		UJ	JUS	JET USA	Ypsilanti Laredo	1994
West Air			PCM	PAC VALLEY	Las Vegas Oakland Ontario Sacramento San Diego	1988
Western Global Airlines		KD	WGN	WESTERN GLOBAL	Miami Liege, Belgium; Anchorage Fort Myers, FL	2013
Wiggins Airways		WG	WIG	WIGGINS AIRWAYS	Manchester	1929

Air ambulances

Airline	Image	IATA	ICAO	Callsign	Primary hubs, secondary hubs	Founded	Notes
AirMed International					Birmingham-Shuttlesworth	1987	Founded as MEDjet International.
Air Methods					Denver-Centennial	1980
Critical Air Medicine						1984
Lifestar
Life Lion

State-run airlines

Airline	Image	IATA	ICAO	Callsign	Primary hubs, secondary hubs	Founded	Notes
Comco						2002
Janet			WWW	JANET	Las Vegas	1972
Justice Prisoner and Alien Transportation System			JUD	JUSTICE	Oklahoma City	1980	Commenced operations in 1995.

See also

• Lists of airlines
• List of airlines of Puerto Rico
• List of airports in the United States
• List of largest airlines in North America
• List of defunct airlines of the United States
• Major airlines of the United States
• Proposed airlines of the United States

References